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Human Lung Epithelial Cells Progressed to Malignancy through Specific Oncogenic Manipulations

1 Mar 2013

Abstract excerpt

We used CDK4/hTERT-immortalized normal human bronchial epithelial cells (HBEC) from several individuals to study lung cancer pathogenesis by introducing combinations of common lung cancer oncogenic changes (p53, KRAS, and MYC) and followed the stepwise transformation of HBECs to full malignancy. This model showed that: (i) the combination of five genetic alterations (CDK4, hTERT, sh-p53, KRAS(V12), and c-MYC) is...

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PMID: 23449933
DOI: 10.1158/1541-7786.mcr-12-0634-t

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