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Article

Human skin neural crest progenitor cells are susceptible to BRAF(V600E)-induced transformation.

Oncogene - 13 Feb 2014

Kumar S M, Dai J, Li S, Yang R, Yu H, Nathanson K L, Liu S, Zhou H, Guo J, Xu X

Abstract excerpt

Adult stem cells are multipotent and persist in small numbers in adult tissues throughout the lifespan of an organism. Unlike differentiated cells, adult stem cells are intrinsically resistant to senescence. It is unclear how adult stem cells in solid organs respond to oncogenic stimulation and whether these cells have a role in tumor initiation. We report here that expression of BRAF(V600E) in human neural crest...

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Source

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Identifiers

PMID: 23334329
DOI: 10.1038/onc.2012.642
PMCID: PMC3695032

Genes

BRAF
MITF
CDK2
CDK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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