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Article

Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells.

Biochemical and biophysical research communications - 30 Apr 2020

Kumazaki Minami, Shimomura Iwao, Kiyono Tohru, Ochiya Takahiro, Yamamoto Yusuke

Abstract excerpt

The oncogenic Ras mutation is one of the most common genomic abnormalities having the highest incidence in cancer; it has three isoforms: Hras, Kras, and Nras. Although the Ras isoforms are highly similar in the primary sequence, each mutational frequency is clearly distinct according to tissue- or cell-type. Regarding non-small-cell lung carcinoma, almost all Kras mutations have been detected in lung...

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Identifiers

PMID: 32111352
DOI: 10.1016/j.bbrc.2020.02.113

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