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Article

ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis.

Cancer gene therapy - 1 May 2021

Bogucka Katarzyna, Marini Federico, Rosigkeit Sebastian, Schloeder Janine, Jonuleit Helmut, David Kerstin, Schlackow Margarita, Rajalingam Krishnaraj

Abstract excerpt

KRAS is one of the most frequently mutated oncogenes, especially in lung cancers. Targeting of KRAS directly or the downstream effector signaling machinery is of prime interest in treating lung cancers. Here, we uncover that ERK3, a ubiquitously expressed atypical MAPK, is required for KRAS-mediated NSCLC tumors. ERK3 is highly expressed in lung cancers, and oncogenic KRAS led to the activation and stabilization...

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PMID: 33070159
DOI: 10.1038/s41417-020-00245-w

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