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Article

Oncogene-mediated human lung epithelial cell transformation produces adenocarcinoma phenotypes in vivo.

Cancer research - 1 Apr 2011

Sasai Ken, Sukezane Taiko, Yanagita Emmy, Nakagawa Harumi, Hotta Azusa, Itoh Tomoo, Akagi Tsuyoshi

Abstract excerpt

It has been challenging to engineer lung adenocarcinoma models via oncogene-mediated transformation of primary cultured normal human cells. Although viral oncoprotein-mediated malignant transformation has been reported, xenografts derived from such transformed cells generally represent poorly differentiated cancers. Here, we demonstrate that the combined expression of multiple cellular factors induces malignant...

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Source

Identifiers

PMID: 21447735
DOI: 10.1158/0008-5472.CAN-10-2221

Genes

KRAS
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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