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Article

Single-cell immunoprofiling reveals a dysfunctional-like immune microenvironment and malignant phenotype in aging penile squamous cell carcinoma.

Cell biology and toxicology - 6 Jun 2026

Cao Jian, Du Lin, Qin Zailong, Ma Aiwei, Bo Hao, Zhao Xueheng, Luo Yanwei, Ou Chunlin, Liu Zhizhong, Xie Yu, Zhang Wancong, Tang Shijie, Tian Yu, Yuan Junbin, Gong Zhaojian, Guo Jie

Abstract excerpt

BACKGROUND: Penile squamous cell carcinoma (PSCC) can affect men of any age, but we know little about the differences between non-old and old patients with PSCC, which severely limits the precise diagnosis and treatment of PSCC. METHODS: We collected 2 non-old and 3 old PSCC samples and performed single-cell RNA sequencing and single-cell TCR-Seq analysis. All samples were subjected to UMAP clustering, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42249992
DOI: 10.1007/s10565-026-10212-0
PMCID: PMC13457360

Genes

MIF
CD24
DCN
EPCAM
GPX4
IL1B
KITLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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