Article
Phospholipase C zeta (PLCζ) and male infertility: Clinical update and topical developments.
Advances in biological regulation - 1 May 2016
Amdani Siti Nornadhirah, Yeste Marc, Jones Celine, Coward Kevin
Abstract excerpt
The development of a mammalian embryo is initiated by a sequence of molecular events collectively referred to as 'oocyte activation' and regulated by the release of intracellular calcium in the ooplasm. Over the last decade, phospholipase C zeta (PLCζ), a sperm protein introduced into the oocyte upon gamete fusion, has gained almost universal acceptance as the protein factor responsible for initiating oocyte...
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