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Article

Identifying latent genetic interactions in genome-wide association studies using multiple traits.

Genome medicine - 25 Apr 2024

Bass Andrew J, Bian Shijia, Wingo Aliza P, Wingo Thomas S, Cutler David J, Epstein Michael P

Abstract excerpt

The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a new kernel-based method called Latent Interaction Testing (LIT) to screen for genetic interactions that leverages pleiotropy from multiple related traits without requiring the interacting variable to be specified or...

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Source

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Identifiers

PMID: 38664839
DOI: 10.1186/s13073-024-01329-0
PMCID: PMC11044415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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