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Article

Fast kernel-based association testing of non-linear genetic effects for biobank-scale data.

Nature communications - 15 Aug 2023

Fu Boyang, Pazokitoroudi Ali, Sudarshan Mukund, Liu Zhengtong, Subramanian Lakshminarayanan, Sankararaman Sriram

Abstract excerpt

Our knowledge of non-linear genetic effects on complex traits remains limited, in part, due to the modest power to detect such effects. While kernel-based tests offer a versatile approach to test for non-linear relationships between sets of genetic variants and traits, current approaches cannot be applied to Biobank-scale datasets containing hundreds of thousands of individuals. We propose, FastKAST, a...

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PMID: 37582955
DOI: 10.1038/s41467-023-40346-2
PMCID: PMC10427662

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