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Article

Chromodomain mutation in S. pombe Kat5/Mst1 affects centromere dynamics and DNA repair.

PloS one - 1 Jan 2024

Li Tingting, Petreaca Ruben C, Forsburg Susan L

Abstract excerpt

KAT5 (S. pombe Mst1, human TIP60) is a MYST family histone acetyltransferase conserved from yeast to humans that is involved in multiple cellular activities. This family is characterized in part by containing a chromodomain, a motif associated with binding methylated histones. We show that a chromodomain mutation in the S. pombe Kat5, mst1-W66R, has defects in pericentromere silencing. mst1-W66R is sensitive to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38662722
DOI: 10.1371/journal.pone.0300732
PMCID: PMC11045136

Genes

KAT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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