Article
Influence of pharmacogenomic polymorphisms on allopurinol-induced cutaneous adverse drug reactions in Thai patients.
BMC medical genomics - 23 Apr 2024
Sornsamdang Gaidganok, Satapornpong Patompong, Jinda Pimonpan, Jantararoungtong Thawinee, Koomdee Napatrupron, Tempark Therdpong, Klaewsongkram Jettanong, Rerkpattanapipat Ticha, Rerknimitr Pawinee, Tuchinda Papapit, Chularojanamontri Leena, Tovanabutra Napatra, Chanprapaph Kumutnart, Disphanurat Wareeporn, Chakkavittumrong Panlop, Srisuttiyakorn Chutika, Srinoulprasert Yuttana, John Shobana, Biswas Mohitosh, Sukasem Chonlaphat
Abstract excerpt
BACKGROUND: Allopurinol has been causing substantial morbidity and mortality particularly in Asian population by producing cutaneous adverse drug reactions (cADRs). Nonetheless, there are no data describing whether other genetics are a valid marker for prediction of allopurinol-induced cADRs patients in addition to HLA-B*58:01 allele. The goal of this study was to identify suitable single nucleotide polymorphisms...
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