Article

Evolutionary diversification of lipid logistics shapes synaptic maturation in primates

2026-07-08

Abstract excerpt

<h4>ABSTRACT</h4> The prolonged developmental trajectory of the human brain (neoteny) is a defining feature of human evolution. Yet, the cellular mechanisms underlying this delay remain poorly understood. Here, comparing human and chimpanzee induced neurons and cerebral organoids, we we show that human neurons form fewer excitatory synapses and synchronize network activity later. Electron microscopy further revea...

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Literature Corpus work: 11f7a1e2-dcfe-5ddf-9c83-207edeca94b0
DOI: 10.64898/2026.07.08.734953

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