Article
Improving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid.
Oncogene - 1 Jun 2024
van der Sluis Karen, van Sandick Johanna W, Vollebergh Marieke A, van Dieren Jolanda M, Hugen Niek, Hartemink Koen J, Veenhof Alexander A F A, Verhoeven Els, van den Berg José G, Snaebjornsson Petur, Noe Michael, van Wezel Tom, Boelens Mirjam C, Kodach Liudmila L
Abstract excerpt
Detection of peritoneal dissemination (PD) in gastric cancer (GC) patients remains challenging. The feasibility of tumor-guided cell-free DNA (cfDNA) detection in prospectively collected peritoneal fluid (ascites and peritoneal lavage) was investigated and compared to conventional cytology in 28 patients. Besides conventional cytology, next generation sequencing was performed on primary tumor DNA and cell-free...
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