Pairwise analysis of plasma cell-free DNA before and after palliative second-line paclitaxel plus ramucirumab treatment in patients with metastatic gastric cancer.

doi:10.1007/s10120-025-01604-y

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Pairwise analysis of plasma cell-free DNA before and after palliative second-line paclitaxel plus ramucirumab treatment in patients with metastatic gastric cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jul 2025

Kim Ji-Won, Kyung Dong Soo, Ko Won Yeong, Kim Hwang-Phill, Hwang Sung-Hyun, Kim Kui-Jin, Lee Ju Hyun, Seo Jeongmin, Kang Minsu, Jung Eun Hee, Suh Koung Jin, Kim Se Hyun, Kim Jin Won, Kim Yu Jung, Kim Jee Hyun, Lee Keun-Wook

Abstract excerpt

BACKGROUND: This study compared plasma cell-free DNA (cfDNA) and tumor tissue DNA (ttDNA) to explore the clinical applicability of cfDNA in patients with metastatic gastric cancer (mGC) receiving palliative second-line paclitaxel + ramucirumab treatment. METHODS: Targeted sequencing of 106 genes was conducted using germline DNA and cfDNA at baseline (baseline-cfDNA) and progressive disease (PD-cfDNA). The results...

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PMID: 40148708
DOI: 10.1007/s10120-025-01604-y
PMCID: PMC12174237

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TP53
APC
CDH1
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