Detection of tumor-derived cell-free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid.

doi:10.1002/cjp2.207

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Article

Detection of tumor-derived cell-free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid.

The journal of pathology. Clinical research - 1 May 2021

Van't Erve Iris, Rovers Koen P, Constantinides Alexander, Bolhuis Karen, Wassenaar Emma Ce, Lurvink Robin J, Huysentruyt Clément J, Snaebjornsson Petur, Boerma Djamila, van den Broek Daan, Buffart Tineke E, Lahaye Max J, Aalbers Arend Gj, Kok Niels Fm, Meijer Gerrit A, Punt Cornelis Ja, Kranenburg Onno, de Hingh Ignace Hjt, Fijneman Remond Ja

Abstract excerpt

Tumor-derived cell-free DNA (cfDNA) is an emerging biomarker for guiding the personalized treatment of patients with metastatic colorectal cancer (CRC). While patients with CRC liver metastases (CRC-LM) have relatively high levels of plasma cfDNA, little is known about patients with CRC peritoneal metastases (CRC-PM). This study evaluated the presence of tumor-derived cfDNA in plasma and peritoneal fluid (i.e....

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PMID: 33635598
DOI: 10.1002/cjp2.207
PMCID: PMC8073000

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