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Article

Effects of stand-alone polar residue on membrane protein stability and structure.

Biochimica et biophysica acta. Biomembranes - 1 Jun 2024

Chang Yu-Chu, Cao Zheng, Chen Wai-Ting, Huang Wei-Chun

Abstract excerpt

Helical membrane proteins generally have a hydrophobic nature, with apolar side chains comprising the majority of the transmembrane (TM) helices. However, whenever polar side chains are present in the TM domain, they often exert a crucial role in structural interactions with other polar residues, such as TM helix associations and oligomerization. Moreover, polar residues in the TM region also often participate in...

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PMID: 38653423
DOI: 10.1016/j.bbamem.2024.184325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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