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Article

Effect of the Lys62Ala Mutation on the Thermal Stability of BstHPr Protein by Molecular Dynamics.

International journal of molecular sciences - 7 Jun 2024

Martínez-Zacarias Aranza C, López-Pérez Edgar, Alas-Guardado Salomón J

Abstract excerpt

We analyzed the thermal stability of the BstHPr protein through the site-directed point mutation Lys62 replaced by Ala residue using molecular dynamics simulations at five different temperatures: 298, 333, 362, 400, and 450 K, for periods of 1 μs and in triplicate. The results from the mutant thermophilic BstHPrm protein were compared with those of the wild-type thermophilic BstHPr protein and the mesophilic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38928023
DOI: 10.3390/ijms25126316
PMCID: PMC11203695

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