Article
Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins.
Nature - 26 Jun 2008
Joh Nathan Hyunjoong, Min Andrew, Faham Salem, Whitelegge Julian P, Yang Duan, Woods Virgil L, Bowie James U
Abstract excerpt
Understanding the energetics of molecular interactions is fundamental to all of the central quests of structural biology including structure prediction and design, mapping evolutionary pathways, learning how mutations cause disease, drug design, and relating structure to function. Hydrogen-bonding is widely regarded as an important force in a membrane environment because of the low dielectric constant of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.