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Article

Revisiting "reverse hydrophobic effect": applicable only to coil mutations at the surface.

Biopolymers - 1 Jul 2009

Gromiha M Michael

Abstract excerpt

In a seminal paper, Pakula and Sauer (Nature, 1990, 344, 363-364) demonstrated that the increase in side-chain hydrophobicity has a reverse relationship with protein stability. We have addressed this problem with several examples of mutants that span at different locations in protein structure based on secondary structure and solvent accessibility. We confirmed that the stability change upon single coil mutation...

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Identifiers

PMID: 19283830
DOI: 10.1002/bip.21187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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