Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative annotation scores of variants for impact on RNA binding protein activities.

Bioinformatics (Oxford, England) - 29 Mar 2024

Duan Jingqi, Gasch Audrey P, Keleş Sündüz

Abstract excerpt

MOTIVATION: The ENCODE project generated a large collection of eCLIP-seq RNA binding protein (RBP) profiling data with accompanying RNA-seq transcriptomes of shRNA knockdown of RBPs. These data could have utility in understanding the functional impact of genetic variants, however their potential has not been fully exploited. We implement INCA (Integrative annotation scores of variants for impact on RBP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Genetic Variation
Share to Molecular Sequence Annotation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA-Binding Proteins

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 38640488
DOI: 10.1093/bioinformatics/btae181
PMCID: PMC11042904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative annotation scores of variants for impact on RNA binding protein activities.PMID 38640488Read ↗

RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteinsSemantic proximity Read ↗

Comprehensive RNA-binding protein analyses and deep learning uncover genetic constraints and disease associations in protein-RNA interfaces.Semantic proximity Read ↗

Discovery of allele-specific protein-RNA interactions in human transcriptomesSemantic proximity Read ↗

The Ensembl Variant Effect PredictorSemantic proximity Read ↗

The IGVF catalog-from genetic variation to function.Semantic proximity Read ↗

Genome-wide landscape of RNA-binding protein dysregulation reveals a major impact on psychiatric disorder riskSemantic proximity Read ↗

A practical guide for the functional annotation of genetic variations using SNPnexus.Semantic proximity Read ↗

Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk.Semantic proximity Read ↗

Regulatory Single-Nucleotide Variant Predictor Increases Predictive Performance of Functional Regulatory Variants.Semantic proximity Read ↗

Bridging sequence-structure motifs and genetic variants for genome-wide dynamic RNA-protein interaction profiling.Semantic proximity Read ↗

CADD v1.7: using protein language models, regulatory CNNs and other nucleotide-level scores to improve genome-wide variant predictions.Semantic proximity Read ↗

Phenotype-specific information improves prediction of functional impact for noncoding variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.