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Article

A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism.

PLoS computational biology - 1 Jul 2016

Mih Nathan, Brunk Elizabeth, Bordbar Aarash, Palsson Bernhard O

Abstract excerpt

Progress in systems medicine brings promise to addressing patient heterogeneity and individualized therapies. Recently, genome-scale models of metabolism have been shown to provide insight into the mechanistic link between drug therapies and systems-level off-target effects while being expanded to explicitly include the three-dimensional structure of proteins. The integration of these molecular-level details,...

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Identifiers

PMID: 27467583
DOI: 10.1371/journal.pcbi.1005039
PMCID: PMC4965186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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