Article
Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation.
Cancer research - 1 Sept 2008
Byron Sara A, Gartside Michael G, Wellens Candice L, Mallon Mary A, Keenan Jack B, Powell Matthew A, Goodfellow Paul J, Pollock Pamela M
Abstract excerpt
KRAS activation and PTEN inactivation are frequent events in endometrial tumorigenesis, occurring in 10% to 30% and 26% to 80% of endometrial cancers, respectively. Because we have recently shown activating mutations in fibroblast growth factor receptor 2 (FGFR2) in 16% of endometrioid endometrial cancers, we sought to determine the genetic context in which FGFR2 mutations occur. Analysis of 116 primary...
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