Article
KIR2DS4 and Its Variant KIR1D in KIR-AA Genotype Donors Showed Differential Survival Impact in Patients with Lymphoid Disease after HLA-Matched Unrelated Hematopoietic Stem Cell Transplantation.
Transplantation and cellular therapy - 1 Jul 2023
Gowdavally Sowmya, Tsamadou Chrysanthi, Platzbecker Uwe, Sala Elisa, Valerius Thomas, Klein Stefan, Kröger Nicolaus, Wulf Gerald, Einsele Hermann, Thurner Lorenz, Schaefer-Eckart Kerstin, Freitag Sebastian, Casper Jochen, Dürholt Mareike, Kaufmann Martin, Hertenstein Bernd, Ringhoffer Mark, Schmeller Sandra, Neuchel Christine, Rode Immanuel, Amann Elisa Maria, Richter Anita, Schrezenmeier Hubert, Mytilineos Joannis, Fuerst Daniel
Abstract excerpt
Previous studies have illustrated associations between the presence of activating killer cell immunoglobulin-like receptor (KIR) genes and lower susceptibility to hematologic malignancies in humans. In addition, favorable hematopoietic stem cell transplantation (HSCT) outcomes have been reported in patients who received transplants from donors with KIR genotypes dominant for activating KIR receptors. However, the...
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