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Article

Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Jun 2024

Qin Guangrong, Dai Jin, Chien Sylvia, Martins Timothy J, Loera Brenda, Nguyen Quy H, Oakes Melanie L, Tercan Bahar, Aguilar Boris, Hagen Lauren, McCune Jeannine, Gelinas Richard, Monnat Raymond J, Shmulevich Ilya, Becker Pamela S

Abstract excerpt

PURPOSE: The inherent genetic heterogeneity of acute myeloid leukemia (AML) has challenged the development of precise and effective therapies. The objective of this study was to elucidate the genomic basis of drug resistance or sensitivity, identify signatures for drug response prediction, and provide resources to the research community. EXPERIMENTAL DESIGN: We performed targeted sequencing, high-throughput drug...

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Share to Acute Myeloid Leukemia Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 38619278
DOI: 10.1158/1078-0432.CCR-23-1674
PMCID: PMC11176916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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