Article
Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia.
Nature cancer - 1 Nov 2020
Oshima Koichi, Zhao Junfei, Pérez-Durán Pablo, Brown Jessie A, Patiño-Galindo Juan Angel, Chu Timothy, Quinn Aidan, Gunning Thomas, Belver Laura, Ambesi-Impiombato Alberto, Tosello Valeria, Wang Zhengqiang, Sulis Maria Luisa, Kato Motohiro, Koh Katsuyoshi, Paganin Maddalena, Basso Giuseppe, Balbin Milagros, Nicolas Concepcion, Gastier-Foster Julie M, Devidas Meenakshi, Loh Mignon L, Paietta Elisabeth, Tallman Martin S, Rowe Jacob M, Litzow Mark, Minden Mark D, Meijerink Jules, Rabadan Raul, Ferrando Adolfo
Abstract excerpt
Multi-agent combination chemotherapy can be curative in acute lymphoblastic leukemia (ALL). Still, patients with primary refractory disease or with relapsed leukemia have a very poor prognosis. Here we integrate an in-depth dissection of the mutational landscape across diagnostic and relapsed pediatric and adult ALL samples with genome-wide CRISPR screen analysis of gene-drug interactions across seven ALL...
Topics
- Adult
- Child
- Drug Resistance, Neoplasm
- Humans
- Mutation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Prognosis