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Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysis

21 May 2025

Abstract excerpt

INTRODUCTION: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by aggressive proliferation and chemoresistance, leading to poor patient outcomes. Despite advances in chemotherapy, resistance mechanisms remain inadequately understood, particularly at the cellular and molecular level. OBJECTIVES: This study aims to elucidate the cellular and molecular mechanisms underlying drug resistance in...

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Acute Myeloid Leukemia Research
Protein Degradation and Inhibitors
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40409464
DOI: 10.1016/j.jare.2025.05.038

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