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Article

Improving predictive accuracy in primary biliary cholangitis: A new genetic risk score.

Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2024

Gerussi Alessio, Cappadona Claudio, Bernasconi Davide Paolo, Cristoferi Laura, Valsecchi Maria Grazia, Carbone Marco, Invernizzi Pietro, Asselta Rosanna

Abstract excerpt

BACKGROUND AND AIMS: Genetic variants influence primary biliary cholangitis (PBC) risk. We established and tested an accurate polygenic risk score (PRS) using these variants. METHODS: Data from two Italian cohorts (OldIT 444 cases, 901 controls; NewIT 255 cases, 579 controls) were analysed. The latest international genome-wide meta-analysis provided effect size estimates. The PRS, together with human leukocyte...

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Identifiers

PMID: 38619000
DOI: 10.1111/liv.15916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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