A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients.

doi:10.1186/s12920-016-0239-9

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A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients.

BMC medical genomics - 6 Jan 2017

Paziewska Agnieszka, Habior Andrzej, Rogowska Agnieszka, Zych Włodzimierz, Goryca Krzysztof, Karczmarski Jakub, Dabrowska Michalina, Ambrozkiewicz Filip, Walewska-Zielecka Bozena, Krawczyk Marek, Cichoz-Lach Halina, Milkiewicz Piotr, Kowalik Agnieszka, Mucha Krzysztof, Raczynska Joanna, Musialik Joanna, Boryczka Grzegorz, Wasilewicz Michal, Ciecko-Michalska Irena, Ferenc Malgorzata, Janiak Maria, Kanikowska Alina, Stankiewicz Rafal, Hartleb Marek, Mach Tomasz, Grzymislawski Marian, Raszeja-Wyszomirska Joanna, Wunsch Ewa, Bobinski Tomasz, Mikula Michal, Ostrowski Jerzy

Abstract excerpt

BACKGROUND: Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are forms of hepatic autoimmunity, and risk for both diseases has a strong genetic component. This study aimed to define the genetic architecture of PBC and PSC within the Polish population. METHODS: Subjects were 443 women with PBC, 120 patients with PSC, and 934 healthy controls recruited from Gastroenterology Departments in...

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Identifiers

PMID: 28056976
DOI: 10.1186/s12920-016-0239-9
PMCID: PMC5217265

Genes

ADGRB3
WWC1

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