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Article

The immunogenetics of primary biliary cirrhosis: A comprehensive review.

Journal of autoimmunity - 1 Nov 2015

Webb G J, Siminovitch K A, Hirschfield G M

Abstract excerpt

Primary biliary cirrhosis (PBC), a classic autoimmune liver disease, is characterised by a progressive T cell predominant lymphocytic cholangitis, and a serologic pattern of reactivity in the form of specific anti-mitochondrial antibodies (AMA). CD4+ T cells are particularly implicated by PBC's cytokine signature, the presence of CD4+ T cells specific to mitochondrial auto-antigens, the expression of MHC II on...

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Source

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Identifiers

PMID: 26250073
DOI: 10.1016/j.jaut.2015.07.004
PMCID: PMC5014907

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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