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Article

IGF-1 rs6218 polymorphisms modulate the susceptibility to age-related cataract.

PeerJ - 1 Jan 2024

Zou Xi, Zhang Jun, Wang Yong, Zhou Dong, Deng Guohua, Liu Zhinan

Abstract excerpt

Background: Single nucleotide polymorphisms (SNPs), as the most abundant form of DNA variation in the human genome, contribute to age-related cataracts (ARC) development. Apoptosis of lens epithelial cells (LECs) is closely related to ARC formation. Insulin-like growth factor 1 (IGF1) contributes to cell apoptosis regulation. Moreover, IGF1 was indicated to exhibit a close association with cataract formation....

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Identifiers

PMID: 38618568
DOI: 10.7717/peerj.17220
PMCID: PMC11011587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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