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Article

Changes in SIRT1 Expression and Its Downstream Pathways in Age-Related Cataract in Humans

18 Apr 2011

Abstract excerpt

PURPOSE: SIRT1, the most well-known sirtuin family (class III histone deacetylases) member, is involved in many age-related diseases. However, no study has demonstrated its relationship with age-related cataract (ARC). This study was to investigate the expression of SIRT1 in human lens epithelial cells, and to observe the changes in SIRT1 expression and its downstream P53 and forkhead box class O (FOXO) proteins...

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Connexins and lens biology
Retinal Diseases and Treatments
Sirtuins and Resveratrol in Medicine

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21501079
DOI: 10.3109/02713683.2011.559301

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