Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative multi-omics quantitative trait loci prioritize CASP7 as a candidate protective gene for cataract.

Medicine - 10 Jul 2026

Yuan Zhengxi, Ding Xiangyu, Fang Xiaolong, Mu Jingqing, Hua Xia

Abstract excerpt

Cataracts are the leading cause of vision loss worldwide. Despite surgery being the only effective treatment, its economic burden highlights the necessity of exploring the pathogenesis of cataracts. In this study, we analyzed 4 large-scale GWAS (genome-wide association study) datasets for cataracts and performed SMR analysis along with heterogeneity in dependent instruments (HEIDI) testing to explore the effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 7
Share to Cataract
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Multiomics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 42432881
DOI: 10.1097/MD.0000000000049709
PMCID: PMC13363043

Genes

CASP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative multi-omics quantitative trait loci prioritize CASP7 as a candidate protective gene for cataract.PMID 42432881Read ↗

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.Semantic proximity Read ↗

Uncovering Novel Genetic Loci and Biological Pathways Associated with Age-Related Cataracts through GWAS Meta-AnalysisSemantic proximity Read ↗

Uncovering genetic loci and biological pathways associated with age-related cataracts through GWAS meta-analysis.Semantic proximity Read ↗

Panel-based targeted exome sequencing reveals novel candidate susceptibility loci for age-related cataracts in Chinese Cohort.Semantic proximity Read ↗

Whole Exome Sequencing Study Uncovers Novel Candidate Genes and Protein-Coding Variants for Cataract.Semantic proximity Read ↗

Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approachesSemantic proximity Read ↗

Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.Semantic proximity Read ↗

The putative causal effect of type 2 diabetes in risk of cataract: a Mendelian randomization study in East AsianSemantic proximity Read ↗

Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults.Semantic proximity Read ↗

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disordersSemantic proximity Read ↗

Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.