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Article

Allelic interaction effects of DNA damage and repair genes on the predisposition to age-related cataract.

PloS one - 1 Jan 2018

Yang Mei, Zhang Junfang, Su Shu, Qin Bai, Kang Lihua, Zhu Rongrong, Guan Huaijin

Abstract excerpt

PURPOSE: Age-related cataract (ARC) is a leading cause of visual impairment and blindness worldwide. DNA damage and malfunction of DNA repair are believed to contribute to the pathogenesis of ARC. Aside from increasing age, the risk factors for ARC appear to be rather complex, and one or more gene variations could play critical roles in the diverse processes of ARC progression. This study aimed to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29689049
DOI: 10.1371/journal.pone.0184478
PMCID: PMC5915686

Genes

ARC
WRN
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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