Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter.

doi:10.1038/srep23206

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Article

Polymorphism rs7278468 is associated with Age-related cataract through decreasing transcriptional activity of the CRYAA promoter.

Scientific reports - 17 Mar 2016

Ma Xiaoyin, Jiao Xiaodong, Ma Zhiwei, Hejtmancik J Fielding

Abstract excerpt

CRYAA plays critical functional roles in lens transparency and opacity, and polymorphisms near CRYAA have been associated with age-related cataract (ARC). This study examines polymorphisms in the CRYAA promoter region for association with ARC and elucidates the mechanisms of this association. Three SNPs nominally associated with ARC were identified in the promoter region of CRYAA: rs3761382 (P = 0.06, OR (Odds...

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Identifiers

PMID: 26984531
DOI: 10.1038/srep23206
PMCID: PMC4794711

Genes

CRYAA
ARC
KLF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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