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Article

Hydrophobic substrate binding pocket remodeling of echinocandin B deacylase based on multi-dimensional rational design.

International journal of biological macromolecules - 1 May 2024

Tang Heng, Zhu Han-Yue, Huang Yin-Feng, Wu Ze-Yu, Zou Shu-Ping, Liu Zhi-Qiang, Zheng Yu-Guo

Abstract excerpt

Actinoplanes utahensis deacylase (AAC)-catalyzed deacylation of echinocandin B (ECB) is a promising method for the synthesis of anidulafungin, the newest of the echinocandin antifungal agents. However, the low activity of AAC significantly limits its practical application. In this work, we have devised a multi-dimensional rational design strategy for AAC, conducting separate analyses on the substrate-binding...

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Identifiers

PMID: 38614185
DOI: 10.1016/j.ijbiomac.2024.131473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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