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Article

Structural insights into the catalytic mechanism of lovastatin hydrolase.

The Journal of biological chemistry - 24 Jan 2020

Liang Yajing, Lu Xuefeng

Abstract excerpt

The lovastatin hydrolase PcEST from the fungus Penicillium chrysogenum exhibits enormous potential for industrial-scale applications in single-step production of monacolin J, the key precursor for synthesis of the cholesterol-lowering drug simvastatin. This enzyme specifically and efficiently catalyzes the conversion of lovastatin to monacolin J but cannot hydrolyze simvastatin. Understanding the catalytic...

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Identifiers

PMID: 31839596
DOI: 10.1074/jbc.RA119.011936
PMCID: PMC6983846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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