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Article

Constitutive NOS Production Is Modulated by Alzheimer's Disease Pathology Depending on APOE Genotype.

International journal of molecular sciences - 27 Mar 2024

Bonomi Chiara Giuseppina, Martorana Alessandro, Fiorelli Denise, Nuccetelli Marzia, Placidi Fabio, Mercuri Nicola Biagio, Motta Caterina

Abstract excerpt

Both the endothelial (eNOS) and the neuronal (nNOS) isoforms of constitutive Nitric Oxide Synthase have been implicated in vascular dysfunctions in Alzheimer's disease (AD). We aimed to explore the relationship between amyloid pathology and NO dynamics by comparing the cerebrospinal fluid (CSF) levels of nNOS and eNOS of 8 healthy controls (HC) and 27 patients with a clinical diagnosis of Alzheimer's disease and...

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Identifiers

PMID: 38612537
DOI: 10.3390/ijms25073725
PMCID: PMC11011586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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