Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 1999

Alvarez R, Alvarez V, Lahoz C H, Martínez C, Peña J, Sánchez J M, Guisasola L M, Salas-Puig J, Morís G, Vidal J A, Ribacoba R, Menes B B, Uría D, Coto E

Abstract excerpt

OBJECTIVES: Several lines of evidence suggest that the endothelial constitutive nitric oxide synthase (ecNOS) and angiotensin converting enzyme (ACE) may have a role in Alzheimer's disease. ACE is widely expressed in the brain, and a DNA polymorphism at the ACE gene has been linked to the risk for late onset Alzheimer's disease. Nitric oxide (NO) production by microglial cells, astrocytes, and brain microvessels...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Endothelium, Vascular

Share to Neuroglia

Share to Nitric Oxide Synthase

Share to Oxidative Stress

Share to Peptidyl-Dipeptidase A

Source

Open in PubMed Open full text

Identifiers

PMID: 10567488
DOI: 10.1136/jnnp.67.6.733
PMCID: PMC1736659

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease.PMID 10567488Read ↗

Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies.Semantic proximity Read ↗

Behavioural effects of the ACE insertion/deletion polymorphism in Alzheimer's disease depend upon stratification according to APOE-ϵ4 carrier status.Semantic proximity Read ↗

Association between angiotensin-converting enzyme and Alzheimer disease.Semantic proximity Read ↗

The ACE gene and Alzheimer's disease susceptibility.Semantic proximity Read ↗

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology.Semantic proximity Read ↗

[Association between Alzheimer's disease and nitric oxide synthase III polymorphism].Semantic proximity Read ↗

Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: implication for pharmacogenomics.Semantic proximity Read ↗

Angiotensin converting enzyme gene polymorphism in Alzheimer's disease.Semantic proximity Read ↗

Angiotensin-converting enzyme polymorphisms AND Alzheimer's disease susceptibility: An updated meta-analysis.Semantic proximity Read ↗

Alzheimer disease risk and genetic variation in ACE: a meta-analysis.Semantic proximity Read ↗

Haplotypes extending across ACE are associated with Alzheimer's disease.Semantic proximity Read ↗

Genetic association between endothelial nitric oxide synthase and Alzheimer disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.