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Article

Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction

10 Apr 2024

Abstract excerpt

BACKGROUND: GPCRs (G-protein-coupled receptors) play a central role in the regulation of smooth muscle cell (SMC) contractility, but the function of SMC-expressed orphan GPCR class C group 5 member C (GPRC5C) is unclear. The aim of this project is to define the role of GPRC5C in SMC in vitro and in vivo. METHODS: We studied the role of GPRC5C in the regulation of SMC contractility and differentiation in human and...

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PMID: 38597112
DOI: 10.1161/circresaha.123.323752

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