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Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

16 Jun 2017

Abstract excerpt

G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR expression analysis in primary smooth muscle cells (SMC) and endothelial cells (EC). GPCR expression is highly heterogeneous in all cell types, which is confirmed in...

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PMID: 28621310
DOI: 10.1038/ncomms15700

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