Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase.

The Journal of biological chemistry - 16 Nov 2007

Zhang Tong, Zhuang Shunhui, Casteel Darren E, Looney David J, Boss Gerry R, Pilz Renate B

Abstract excerpt

Vascular smooth muscle cells (VSMCs) undergo phenotypic modulation, changing from a differentiated, contractile to a de-differentiated, synthetic phenotype; the change is associated with decreased expression of smooth muscle (SM)-specific genes and loss of cGMP-dependent protein kinase (PKG), but transfection of PKG into de-differentiated VSMCs restores SM-specific gene expression. We show that small interference...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Defensins
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Cyclic GMP-Dependent Protein Kinases

Share to Cysteine

Share to Gene Expression Regulation, Enzymologic

Share to Muscle, Smooth

Share to rhoA GTP-Binding Protein

Source

Identifiers

PMID: 17878170
DOI: 10.1074/jbc.M707186200

Genes

SRF
GATA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase.PMID 17878170Read ↗

Serum response factor-dependent MicroRNAs regulate gastrointestinal smooth muscle cell phenotypes.Semantic proximity Read ↗

Transcriptional control of a novel long noncoding RNA Mymsl in smooth muscle cells by a single Cis-element and its initial functional characterization in vessels.Semantic proximity Read ↗

Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells.Semantic proximity Read ↗

Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation.Semantic proximity Read ↗

PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.Semantic proximity Read ↗

Intronic CArG box regulates cysteine-rich protein 2 expression in the adult but not in developing vasculature.Semantic proximity Read ↗

Myocardin: a component of a molecular switch for smooth muscle differentiation.Semantic proximity Read ↗

The Smooth Muscle Cell-restricted KCNMB1 Ion Channel Subunit Is a Direct Transcriptional Target of Serum Response Factor and MyocardinSemantic proximity Read ↗

Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation.Semantic proximity Read ↗

Spry1 and Spry4 differentially regulate human aortic smooth muscle cell phenotype via Akt/FoxO/myocardin signaling.Semantic proximity Read ↗

Mitogen-activated protein kinase 14 is a novel negative regulatory switch for the vascular smooth muscle cell contractile gene program.Semantic proximity Read ↗

Embryonic Expression Suggests an Important Role for CRP2/SmLIM in the Developing Cardiovascular SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.