Article
The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations.
Current opinion in structural biology - 1 Dec 2021
Abdelkarim Hazem, Leschinsky Nicholas, Jang Hyunbum, Banerjee Avik, Nussinov Ruth, Gaponenko Vadim
Abstract excerpt
Oncogenic mutant K-Ras promotes cancer cell proliferation, migration, invasion, and survival by assembling signaling complexes. To date, the functional and structural roles of K-Ras mutations within these complexes are incompletely understood despite their mechanistic and therapeutic significance. Here, we review recent advances in understanding specific binding between K-Ras and the calcium sensor calmodulin....
Topics
- Calcium
- Calmodulin
- Humans
- Mutation
- Neoplasms
- Proto-Oncogene Proteins p21(ras)
- Signal Transduction