Article
Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation.
The Journal of general physiology - 7 Dec 2020
Ledford Hannah A, Park Seojin, Muir Duncan, Woltz Ryan L, Ren Lu, Nguyen Phuong T, Sirish Padmini, Wang Wenying, Sihn Choong-Ryoul, George Alfred L, Knollmann Björn C, Yamoah Ebenezer N, Yarov-Yarovoy Vladimir, Zhang Xiao-Dong, Chiamvimonvat Nipavan
Abstract excerpt
Calmodulin (CaM) plays a critical role in intracellular signaling and regulation of Ca2+-dependent proteins and ion channels. Mutations in CaM cause life-threatening cardiac arrhythmias. Among the known CaM targets, small-conductance Ca2+-activated K+ (SK) channels are unique, since they are gated solely by beat-to-beat changes in intracellular Ca2+. However, the molecular mechanisms of how CaM mutations may...
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