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Colon Cancer and Perturbations of the Sphingolipid Metabolism

30 Nov 2019

Abstract excerpt

The development and progression of colorectal cancer (CRC), a major cause of cancer-related death in the western world, is accompanied with alterations of sphingolipid (SL) composition in colon tumors. A number of enzymes involved in the SL metabolism have been found to be deregulated in human colon tumors, in experimental rodent studies, and in human colon cancer cells in vitro. Therefore, the enzymatic pathways...

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PMID: 31801289
DOI: 10.3390/ijms20236051

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