Accelerated somatic mutation calling for whole-genome and whole-exome sequencing data from heterogenous tumor samples.

Abstract excerpt

Accurate detection of somatic mutations in DNA sequencing data is a fundamental prerequisite for cancer research. Previous analytical challenges were overcome by consensus mutation calling from four to five popular callers. This, however, increases the already nontrivial computing time from individual callers. Here, we launch MuSE 2, powered by multistep parallelization and efficient memory allocation, to resolve...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Exome Sequencing
• Share to Algorithms
• Share to DNA Mutational Analysis