Article
Halvade somatic: Somatic variant calling with Apache Spark.
GigaScience - 12 Jan 2022
Decap Dries, de Schaetzen van Brienen Louise, Larmuseau Maarten, Costanza Pascal, Herzeel Charlotte, Wuyts Roel, Marchal Kathleen, Fostier Jan
Abstract excerpt
BACKGROUND: The accurate detection of somatic variants from sequencing data is of key importance for cancer treatment and research. Somatic variant calling requires a high sequencing depth of the tumor sample, especially when the detection of low-frequency variants is also desired. In turn, this leads to large volumes of raw sequencing data to process and hence, large computational requirements. For example,...
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