Article

Rigorous software pipeline for clinical somatic mutation analyses of solid tumors

2023-06-14

Abstract excerpt

Mutational analyses of tumor DNA guide the use of targeted therapies and checkpoint inhibitors in management of solid tumors. Reducing false positive mutation calls without compromising sensitivity as gene panels increase in size, and whole exome and genome sequencing enters clinical use, remains a major challenge. Aiming for robust somatic mutation analyses in the clinical setting, we have developed VARify, an in...

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Literature Corpus work: d7524aa2-dfb1-52aa-8b0f-65d9978eac72
DOI: 10.1101/2023.06.08.23291143

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