Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort.

Journal of hepatology - 1 Sept 2024

Chen Vincent L, Du Xiaomeng, Oliveri Antonino, Chen Yanhua, Kuppa Annapurna, Halligan Brian D, Province Michael A, Speliotes Elizabeth K

Abstract excerpt

BACKGROUND & AIMS: Steatotic liver disease (SLD), characterized by elevated liver fat content (LFC), is influenced by genetics and diet. However, whether diet has a differential effect based on genetic risk is not well-characterized. We aimed to determine how genetic factors interact with diet to affect SLD in a large national biobank. METHODS: We included UK Biobank participants with dietary intake measured by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Diet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, Mediterranean

Share to Fatty Liver

Share to Lipase

Share to Liver Cirrhosis

Share to Non-alcoholic Fatty Liver Disease

Share to Phospholipases A2, Calcium-Independent

Source

Open in PubMed Open full text

Identifiers

PMID: 38582304
DOI: 10.1016/j.jhep.2024.03.045
PMCID: PMC11347099

Genes

PNPLA3
TM6SF2
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort.PMID 38582304Read ↗

Genetic risk amplifies lifestyle effects on hepatic steatosis and its progression: Insights from a population-based cohort.Semantic proximity Read ↗

TM6SF2-rs58542926 Genetic Variant Modifies the Protective Effect of a "Prudent" Dietary Pattern on Serum Triglyceride Levels.Semantic proximity Read ↗

The impact of genetic and environmental risk factors on adverse liver outcomes.Semantic proximity Read ↗

Modifiable lifestyle factors, genetic and acquired risk, and the risk of severe liver disease in the UK Biobank cohort: (Lifestyle factors and SLD).Semantic proximity Read ↗

Associations of Alcohol Consumption and Genetic Predisposition to Hepatic Steatosis With Liver-Related Events: Results From Large Population-Based Cohort Studies.Semantic proximity Read ↗

A Polygenic Risk Score to Refine Risk Stratification and Prediction for Severe Liver Disease by Clinical Fibrosis ScoresSemantic proximity Read ↗

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content.Semantic proximity Read ↗

Genetic and metabolic aspects of non-alcoholic fatty liver disease (NAFLD) pathogenicitySemantic proximity Read ↗

Human genetics of metabolic dysfunction–associated steatotic liver disease: from variants to cause to precision treatmentSemantic proximity Read ↗

Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer.Semantic proximity Read ↗

Metabolic effects of risk alleles in <i>PNPLA3, TM6SF2, GCKR</i> and <i>LYPLAL1</i> inform about heterogeneity of non-alcoholic fatty liver diseaseSemantic proximity Read ↗

Unravelling genetic susceptibility and causal factors in liver health using MRI quantification of inflammation, fat and iron in the liver.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.