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Article

Unravelling genetic susceptibility and causal factors in liver health using MRI quantification of inflammation, fat and iron in the liver.

Human genomics - 28 Feb 2026

Meena Devendra, Pansini Michele, Fichera Alessandro, Huang Jingxian, Ahmed Altayeb, Dehghan Abbas, Banerjee Rajarshi, Yaghootkar Hanieh

Abstract excerpt

BACKGROUND: Liver steatosis, fibroinflammation, and iron overload, are growing global health concerns, yet the genetic architecture and causal pathways linking liver pathology to systemic disease remain incompletely understood. METHODS: We analysed MRI-derived liver traits—corrected T1 (cT1), proton density fat fraction (PDFF), and liver iron—in 37,626 UK Biobank participants. Genome-wide (GWAS),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41761370
DOI: 10.1186/s40246-026-00913-2
PMCID: PMC13019979

Genes

FADS1
GPN1
RAB2B
FUT2
GPAM
GSTM1
GSTM4
IMPACT
MBOAT7
RAD51C
TMC4
TMPRSS6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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