Article

Generation of circulating autoreactive pre-plasma cells fueled by naïve B cells in celiac disease

2023-10-23

Abstract excerpt

<h4>ABSTRACT</h4> Autoantibodies against the enzyme transglutaminase 2 (TG2) are characteristic of celiac disease (CeD), and TG2-specific IgA plasma cells are abundant in gut biopsies of patients. We here describe the corresponding population of autoreactive B cells in blood. Circulating TG2-specific IgA cells were found in untreated patients on a gluten-containing diet but not in controls. They were clonally rel...

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Literature Corpus work: 2cc05292-80f9-5a1e-b929-f25c77f54bd0
DOI: 10.1101/2023.10.20.563227

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